Emerging role of exosome-derived non-coding RNAs in tumor-associated angiogenesis of tumor microenvironment

The tumor microenvironment (TME) is an intricate ecosystem that actively involved in various stages of cancer occurrence and development. Some characteristics biological behavior, such as proliferation, migration, invasion, inhibition apoptosis, immune escape, angiogenesis, metabolic reprogramming, are affected by TME. Studies have shown non-coding RNAs, especially long-chain RNAs microRNAs cancer-derived exosomes, facilitate intercellular communication a mechanism for regulating angiogenesis. They stimulate growth, well metastasis, reprogramming the Exploring relationship between exogenous tumor-associated endothelial cells, their role clinicians will gain new insights into treatment result.